PDBsum entry 8z9o

Membrane protein/immune system

PDB id: 8z9o

Contents

Protein chains

338 a.a.

220 a.a.

57 a.a.

126 a.a.

303 a.a.

Ligands

CLR ×2

Waters ×1

PDB id:

8z9o

Name:

Membrane protein/immune system

Title:

Cryo-em structure of human gpr4-gs complex

Structure:

Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: c. Synonym: adenylate cyclase-stimulating g alpha protein.

Source:

Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: gnb1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Homo sapiens. Human. Organism_taxid: 9606.

Authors:

L.N.Chen,C.Y.Mao,S.Z.Cheng,Y.F.Liu,Y.F.Fu,X.Y.Ma,P.Xu,S.Y.Ji, W.W.Wang,D.D.Shen,H.B.Zhang,Q.Y.Shen,R.Chai,M.Zhang,L.Yang,F.Han, C.Y.Mao,X.J.Cai,Y.Zhang

Key ref:

L.N.Chen et al. Cryo-Em structure of human gpr4-Gs complex. To be published, .

Date:

23-Apr-24 Release date: 16-Jul-25

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 220 a.a.*

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

Protein chain

P46093  (GPR4_HUMAN) -  G-prodeshotein coupled receptor 4 from Homo sapiens

Seq: 362 a.a.

Struc: 303 a.a.

* PDB and UniProt seqs differ at 48 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain C: E.C.3.6.5.- - ?????