PDBsum entry 8yyw

Membrane protein

PDB id: 8yyw

Contents

Protein chains

232 a.a.

339 a.a.

57 a.a.

300 a.a.

225 a.a.

Ligands

AKG ×2

PDB id:

8yyw

Name:

Membrane protein

Title:

Cryo-em structure of oxgr1 bound to alpha-ketoglutarate and gq proteins

Structure:

Scfv16. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: c. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit

Source:

Vicugna pacos. Organism_taxid: 30538. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606. Gene: gnb1. Gene: gng2.

Authors:

A.Liu,Y.Liu

Key ref:

A.Liu and y.liu Cryo-Em structure of oxgr1 bound to alpha-Ketoglutara. To be published, .

Date:

04-Apr-24 Release date: 09-Apr-25

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

Q96P68  (OXGR1_HUMAN) -  2-oxoglutarate receptor 1 from Homo sapiens

Seq: 337 a.a.

Struc: 300 a.a.

Protein chain

P50148  (GNAQ_HUMAN) -  Guanine nucleotide-binding protein G(q) subunit alpha from Homo sapiens

Seq: 359 a.a.

Struc: 225 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 225 a.a.*

* PDB and UniProt seqs differ at 130 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain F: E.C.3.6.5.- - ?????