PDBsum entry 8ykd

Membrane protein

PDB id: 8ykd

Contents

Protein chains

233 a.a.

337 a.a.

55 a.a.

127 a.a.

240 a.a.

233 a.a.

Ligands

AND

PDB id:

8ykd

Name:

Membrane protein

Title:

Cryo-em structure of adgrg2-gs complex with ntf nanobody

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha. Chain: a. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Spodoptera. Organism_taxid: 7106. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590. Gene: gnb1. Gene: mrhifer1_005810. Gene: adgrg2, gpr64, me6. Expression_system_taxid: 274590

Authors:

S.M.Huang,G.Sheng-Chao

Key ref:

Y.Zheng et al. Development of an allosteric adhesion gpcr nanobody w therapeutic potential. Nat chem biol, . PubMed id: 40374856

Date:

04-Mar-24 Release date: 13-Aug-25

Protein chain

P63091  (GNAS_CANLF) -  Guanine nucleotide-binding protein G(s) subunit alpha from Canis lupus familiaris

Seq: 394 a.a.

Struc: 233 a.a.*

Protein chain

P62871  (GBB1_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Bos taurus

Seq: 340 a.a.

Struc: 337 a.a.

Protein chain

A0A7J7XNR4  (A0A7J7XNR4_RHIFE) -  Guanine nucleotide-binding protein subunit gamma from Rhinolophus ferrumequinum

Seq: 99 a.a.

Struc: 55 a.a.

Protein chain

No UniProt id for this chain

Struc: 127 a.a.

Protein chain

Q8CJ12  (AGRG2_MOUSE) -  Adhesion G-protein coupled receptor G2 from Mus musculus

Seq: 1009 a.a.

Struc: 240 a.a.

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

* PDB and UniProt seqs differ at 48 residue positions (black crosses)