PDBsum entry 8yk0

Membrane protein

PDB id: 8yk0

Contents

Protein chains

298 a.a.

338 a.a.

57 a.a.

222 a.a.

317 a.a.

Ligands

MW9 ×4

CLR ×11

PDB id:

8yk0

Name:

Membrane protein

Title:

Cryo-em structure of human gpr156-gi3 complex

Structure:

Probable g-protein coupled receptor 156. Chain: b. Synonym: g-protein coupled receptor pgr28,gabab-related g-protein coupled receptor. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: d. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gpr156, gababl, pgr28. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Rattus norvegicus. Norway rat. Organism_taxid: 10116.

Authors:

X.Y.Ma,L.N.Chen,M.H.Liao,L.Y.Zhang,K.Xi,J.M.Guo

Key ref:

X.Ma et al. (2024). Molecular insights into the activation mechanism of g in maintaining auditory function.. Nat commun, 15, 10601. PubMed id: 39638804

Date:

03-Mar-24 Release date: 05-Feb-25

Protein chain

Q8NFN8  (GP156_HUMAN) -  Probable G-protein coupled receptor 156 from Homo sapiens

Seq: 814 a.a.

Struc: 298 a.a.

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

P08754  (GNAI3_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-3 from Homo sapiens

Seq: 354 a.a.

Struc: 222 a.a.*

Protein chain

Q8NFN8  (GP156_HUMAN) -  Probable G-protein coupled receptor 156 from Homo sapiens

Seq: 814 a.a.

Struc: 317 a.a.

* PDB and UniProt seqs differ at 4 residue positions (black crosses)