Human fl metabotropic glutamate receptor 5, mglu5-5m with quisqualate, acc conformation (purified with pam vu0409551 but not modelled)
Structure:
Metabotropic glutamate receptor 5. Chain: a, b. Engineered: yes. Mutation: yes. Other_details: the construct has tags and protease cleavage site at its n-term (dykddddkhhhhhhhhhhlevlfqgp) and when compared to uniprot it starts at 21 and ends at 856. For cryoem, the tag is cleaved and the protein used for experiment starts at qsse but residues starting rr have been modeled. There are 5 thermostabilising mutations (t742a,
Source:
Homo sapiens. Human. Organism_taxid: 9606. Gene: grm5. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293 gnti-.
Authors:
K.R.Vinothkumar,G.Lebon,G.Cannone
Key ref:
K.R.Vinothkumar
et al.
Conformational diversity in class c gpcr positive all modulation.
To be published,
.
PubMed id: 39805839
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