PDBsum entry 8wvu

Structural protein

PDB id: 8wvu

Contents

Protein chains

733 a.a.

102 a.a.

137 a.a.

PDB id:

8wvu

Name:

Structural protein

Title:

Cryo-em structure of lgr4 in complex with rspo1 and rnf43

Structure:

Leucine-rich repeat-containing g-protein coupled receptor 4. Chain: a. Engineered: yes. R-spondin-1. Chain: b. Synonym: roof plate-specific spondin-1,hrspo1. Engineered: yes. E3 ubiquitin-protein ligase rnf43.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: lgr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: rspo1. Gene: rnf43. Expression_system_taxid: 7108

Authors:

Z.Chang,C.Lin

Key ref:

C.Lin and z.chang Cryo-Em structure of lgr4 in complex with rspo1 and r. To be published, .

Date:

24-Oct-23 Release date: 30-Oct-24

Protein chain

Q9BXB1  (LGR4_HUMAN) -  Leucine-rich repeat-containing G-protein coupled receptor 4 from Homo sapiens

Seq: 951 a.a.

Struc: 733 a.a.

Protein chain

Q2MKA7  (RSPO1_HUMAN) -  R-spondin-1 from Homo sapiens

Seq: 263 a.a.

Struc: 102 a.a.

Protein chain

Q68DV7  (RNF43_HUMAN) -  E3 ubiquitin-protein ligase RNF43 from Homo sapiens

Seq: 783 a.a.

Struc: 137 a.a.

Enzyme reactions

• Enzyme class: Chain C: E.C.2.3.2.27 - RING-type E3 ubiquitin transferase.
• Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆- ubiquitinyl-[acceptor protein]-L-lysine