PDBsum entry 8wpu

Membrane protein

PDB id: 8wpu

Contents

Protein chains

808 a.a.

217 a.a.

341 a.a.

55 a.a.

229 a.a.

Ligands

NAG-NAG ×2

NAG ×9

YP4 ×2

TRP ×2

PO4 ×2

CLR

Metals

_CA ×4

PDB id:

8wpu

Name:

Membrane protein

Title:

Human calcium-sensing receptor(casr) bound to cinacalcet in complex with gq protein

Structure:

Extracellular calcium-sensing receptor,calcium-sensing receptor. Chain: b, a. Synonym: car,casr,hcasr,parathyroid cell calcium-sensing receptor 1, pcar1. Engineered: yes. G subunit q (gi2-mini-gq chimeric). Chain: g. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: casr, gprc2a, pcar1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Rattus norvegicus.

Authors:

S.L.Ling,X.Y.Meng,C.L.Tian

Key ref:

S.Ling et al. Structural insights into asymmetric activation of the calcium-Sensing receptor-G q complex.. Cell res, . PubMed id: 37919470

Date:

10-Oct-23 Release date: 22-Nov-23

Protein chains

P41180  (CASR_HUMAN) -  Extracellular calcium-sensing receptor from Homo sapiens

Seq: 1078 a.a.

Struc: 808 a.a.

Protein chain

P04899  (GNAI2_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-2 from Homo sapiens

Seq: 355 a.a.

Struc: 217 a.a.*

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 217 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 341 a.a.*

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

No UniProt id for this chain

Struc: 229 a.a.

* PDB and UniProt seqs differ at 202 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain G: E.C.3.6.5.- - ?????