PDBsum entry 8th4

Signaling protein/immune system

PDB id: 8th4

Contents

Protein chains

382 a.a.

122 a.a.

106 a.a.

112 a.a.

Ligands

LSN

PDB id:

8th4

Name:

Signaling protein/immune system

Title:

Structure of at118-l nanobody antagonist in complex with the angiotensin ii type i receptor and losartan

Structure:

Type-1 angiotensin ii receptor soluble cytochrome b562 complex. Chain: a. Synonym: at1ar,at1br,angiotensin ii type-1 receptor,at1 receptor, cytochrome b-562. Engineered: yes. Bag2 anti-bril fab heavy chain. Chain: c. Engineered: yes.

Source:

Homo sapiens, escherichia coli. Human. Organism_taxid: 9606, 562. Gene: agtr1, agtr1a, agtr1b, at2r1, at2r1b, cybc. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell: expi293 tet-r. Synthetic construct. Organism_taxid: 32630.

Authors:

M.A.Skiba,A.C.Kruse

Key ref:

M.A.Skiba et al. Antibodies expand the scope of angiotensin receptor pharmacology. Nat chem biol, . PubMed id: 38744986

Date:

13-Jul-23 Release date: 22-May-24

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 382 a.a.*

Protein chain

P30556  (AGTR1_HUMAN) -  Type-1 angiotensin II receptor from Homo sapiens

Seq: 359 a.a.

Struc: 382 a.a.*

Protein chain

No UniProt id for this chain

Struc: 122 a.a.

Protein chain

No UniProt id for this chain

Struc: 106 a.a.

Protein chain

No UniProt id for this chain

Struc: 112 a.a.

* PDB and UniProt seqs differ at 121 residue positions (black crosses)