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UniProt functional annotation for P30556 | ||
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| UniProt code: P30556. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. |
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| Function: | |
(Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2- dependent endocytosis. {ECO:0000269|PubMed:33713620}. |
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| Subunit: | |
Interacts with MAS1 (Probable) (PubMed:15809376). Interacts with ARRB1 (By similarity). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884). {ECO:0000250|UniProtKB:P25095, ECO:0000269|PubMed:15809376, ECO:0000269|PubMed:26460884, ECO:0000305}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:33713620}; Multi-pass membrane protein {ECO:0000255}. |
| Tissue specificity: | |
Liver, lung, adrenal and adrenocortical adenomas. |
| Ptm: | |
C-terminal Ser or Thr residues may be phosphorylated. |
| Disease: | |
Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269|PubMed:16116425}. Note=The disease is caused by variants affecting the gene represented in this entry. |
| Similarity: | |
Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
Annotations taken from UniProtKB at the EBI.