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PDBsum entry 8tb7
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protein ligands Protein-protein interface(s) links
Signaling protein PDB id
8tb7

 

 

 

 

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Contents
Protein chains
328 a.a.
222 a.a.
117 a.a.
212 a.a.
Ligands
ZOB
Waters ×1
PDB id:
8tb7
Name: Signaling protein
Title: Cryo-em structure of gpr61-
Structure: G-protein coupled receptor 61,soluble cytochrome b562. Chain: r. Engineered: yes. Fab24 bak5 heavy chain. Chain: h. Engineered: yes. Fab hinge-binding nanobody. Chain: n. Engineered: yes.
Source: Homo sapiens, escherichia coli. Human. Organism_taxid: 9606, 562. Gene: gpr61, cybc. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Organism_taxid: 9606. Expressed in: homo sapiens.
Authors: J.A.Lees,J.M.Dias,S.Han
Key ref: J.A.Lees et al. (2023). An inverse agonist of orphan receptor gpr61 acts by a protein-Competitive allosteric mechanism.. Nat commun, 14, 5938. PubMed id: 37741852
Date:
28-Jun-23     Release date:   04-Oct-23    
PROCHECK
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 Headers
 References

Protein chain
P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli
Seq:
Struc: 		128 a.a.
328 a.a.*
Protein chain
Q9BZJ8  (GPR61_HUMAN) -  G-protein coupled receptor 61 from Homo sapiens
Seq:
Struc: 		451 a.a.
328 a.a.*
Protein chain
No UniProt id for this chain
Struc: 222 a.a.
Protein chain
No UniProt id for this chain
Struc: 117 a.a.
Protein chain
No UniProt id for this chain
Struc: 212 a.a.
Key:    Secondary structure
* PDB and UniProt seqs differ at 124 residue positions (black crosses)

 

 

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