UniProt functional annotation for Q9BZJ8



	UniProt functional annotation for Q9BZJ8

UniProt code: Q9BZJ8.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). May be involved in the regulation of food intake and body weight (By similarity). {ECO:0000250|UniProtKB:Q8C010, ECO:0000269|PubMed:28827538}.

Subunit: Forms heterodimer with MTNR1B (PubMed:28827538). Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR61 in the endosomal compartment (PubMed:28827538). {ECO:0000269|PubMed:28827538}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:28827538, ECO:0000269|PubMed:29226084}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:28827538}; Multi- pass membrane protein {ECO:0000255}. Note=Colocalizes with ARRB2/beta- arrestin-2 in the endosome (PubMed:28827538). {ECO:0000269|PubMed:28827538}.

Tissue specificity: Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus (PubMed:11690637, PubMed:29226084). Also expressed in testis (PubMed:11690637, PubMed:29226084) and T cells, B cells, and monocyte (PubMed:29226084). Low expression in many other tissues (PubMed:11690637, PubMed:29226084). Widely expressed in the hippocampus (at protein level). {ECO:0000269|PubMed:11690637, ECO:0000269|PubMed:29226084}.

Similarity: Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.

Sequence caution: Sequence=AAK12637.1; Type=Frameshift; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). May be involved in the regulation of food intake and body weight (By similarity). {ECO:0000250\|UniProtKB:Q8C010, ECO:0000269\|PubMed:28827538}.


Subunit:		Forms heterodimer with MTNR1B (PubMed:28827538). Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR61 in the endosomal compartment (PubMed:28827538). {ECO:0000269\|PubMed:28827538}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:28827538, ECO:0000269\|PubMed:29226084}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269\|PubMed:28827538}; Multi- pass membrane protein {ECO:0000255}. Note=Colocalizes with ARRB2/beta- arrestin-2 in the endosome (PubMed:28827538). {ECO:0000269\|PubMed:28827538}.
Tissue specificity:		Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus (PubMed:11690637, PubMed:29226084). Also expressed in testis (PubMed:11690637, PubMed:29226084) and T cells, B cells, and monocyte (PubMed:29226084). Low expression in many other tissues (PubMed:11690637, PubMed:29226084). Widely expressed in the hippocampus (at protein level). {ECO:0000269\|PubMed:11690637, ECO:0000269\|PubMed:29226084}.
Similarity:		Belongs to the G-protein coupled receptor 1 family. {ECO:0000255\|PROSITE-ProRule:PRU00521}.
Sequence caution:		Sequence=AAK12637.1; Type=Frameshift; Evidence={ECO:0000305};