PDBsum entry 8szi

Signaling protein

PDB id: 8szi

Contents

Protein chains

223 a.a.

338 a.a.

57 a.a.

826 a.a.

Ligands

NAG-NAG ×3

PCW ×2

NAG ×3

TRP ×3

PO4 ×2

CLR

Metals

_CA ×4

PDB id:

8szi

Name:

Signaling protein

Title:

Cryo-em structure of pam-free human calcium-sensing receptor casr-gi complex in lipid nanodiscs

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-3. Chain: c. Synonym: g(i) alpha-3. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: d. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Gene: casr, gprc2a, pcar1.

Authors:

F.He,C.Wu,Y.Gao,G.Skiniotis

Key ref:

F.He et al. Allosteric modulation and g-Protein selectivity of th ca2+-Sensing receptor. Nature, . PubMed id: 38326620

Date:

29-May-23 Release date: 07-Feb-24

Protein chain

P08754  (GNAI3_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-3 from Homo sapiens

Seq: 354 a.a.

Struc: 223 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chains

P41180  (CASR_HUMAN) -  Extracellular calcium-sensing receptor from Homo sapiens

Seq: 1078 a.a.

Struc: 826 a.a.

* PDB and UniProt seqs differ at 4 residue positions (black crosses)