PDBsum entry 8szg

Signaling protein

PDB id: 8szg

Contents

Protein chains

335 a.a.

55 a.a.

830 a.a.

219 a.a.

Ligands

NAG-NAG ×3

YP4 ×2

NAG ×4

PCW

SPM ×3

TRP ×2

PO4 ×2

CLR

Metals

_CA ×3

Waters ×1

PDB id:

8szg

Name:

Signaling protein

Title:

Cryo-em structure of cinacalcet-bound human calcium-sensing receptor casr-gq complex in lipid nanodiscs

Structure:

Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: d. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2. Chain: e. Synonym: g gamma-i. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gng2. Gene: casr, gprc2a, pcar1. Gene: gnaq, gaq.

Authors:

F.He,C.Wu,Y.Gao,G.Skiniotis

Key ref:

F.He et al. Allosteric modulation and g-Protein selectivity of th ca2+-Sensing receptor. Nature, . PubMed id: 38326620

Date:

29-May-23 Release date: 07-Feb-24

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 335 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chains

P41180  (CASR_HUMAN) -  Extracellular calcium-sensing receptor from Homo sapiens

Seq: 1078 a.a.

Struc: 830 a.a.

Protein chain

P50148  (GNAQ_HUMAN) -  Guanine nucleotide-binding protein G(q) subunit alpha from Homo sapiens

Seq: 359 a.a.

Struc: 219 a.a.*

* PDB and UniProt seqs differ at 45 residue positions (black crosses)