PDBsum entry 8sg1

Signaling protein

PDB id: 8sg1

Contents

Protein chains

279 a.a.

336 a.a.

54 a.a.

217 a.a.

232 a.a.

Ligands

TYR-PHE-PRO-GLY-GLN-PHE-ALA-PHE-SER

CLR

PLM ×2

PDB id:

8sg1

Name:

Signaling protein

Title:

Cryo-em structure of cmklr1 signaling complex

Structure:

Chemerin-like receptor 1. Chain: r. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cmklr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Gene: gnai1.

Authors:

X.Zhang,C.Zhang

Key ref:

X.Zhang and c.zhang Cryo-Em structure of cmklr1 signaling complex. To be published, . PubMed id: 38055679

Date:

11-Apr-23 Release date: 01-Nov-23

Protein chain

Q99788  (CML1_HUMAN) -  Chemerin-like receptor 1 from Homo sapiens

Seq: 373 a.a.

Struc: 279 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 336 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 54 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 217 a.a.*

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????