UniProt functional annotation for Q99788



	UniProt functional annotation for Q99788

UniProt code: Q99788.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down- regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). {ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:20044979, ECO:0000269|PubMed:9603476}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:16863918}; Multi-pass membrane protein {ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:16863918}.

Tissue specificity: Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes. {ECO:0000269|PubMed:14530373, ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:18242188, ECO:0000269|PubMed:20044979, ECO:0000269|PubMed:8976386}.

Developmental stage: Expressed during bone development.

Induction: Up-regulated by inflammatory cytokines TNF-alpha and IFN- gamma in monocytes. Up-regulated by TNF-alpha, IL-1-beta and IL-6 in endothelial cells. {ECO:0000269|PubMed:14530373, ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:20044979}.

Miscellaneous: [Isoform A]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Similarity: Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down- regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). {ECO:0000269\|PubMed:15728234, ECO:0000269\|PubMed:15753205, ECO:0000269\|PubMed:20044979, ECO:0000269\|PubMed:9603476}.


Subcellular location:		Cell membrane {ECO:0000269\|PubMed:15728234, ECO:0000269\|PubMed:16863918}; Multi-pass membrane protein {ECO:0000269\|PubMed:15728234, ECO:0000269\|PubMed:16863918}.
Tissue specificity:		Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes. {ECO:0000269\|PubMed:14530373, ECO:0000269\|PubMed:15728234, ECO:0000269\|PubMed:15753205, ECO:0000269\|PubMed:18242188, ECO:0000269\|PubMed:20044979, ECO:0000269\|PubMed:8976386}.
Developmental stage:		Expressed during bone development.
Induction:		Up-regulated by inflammatory cytokines TNF-alpha and IFN- gamma in monocytes. Up-regulated by TNF-alpha, IL-1-beta and IL-6 in endothelial cells. {ECO:0000269\|PubMed:14530373, ECO:0000269\|PubMed:15753205, ECO:0000269\|PubMed:20044979}.
Miscellaneous:		[Isoform A]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Similarity:		Belongs to the G-protein coupled receptor 1 family. {ECO:0000255\|PROSITE-ProRule:PRU00521}.