PDBsum entry 8rql

Structural protein

PDB id: 8rql

Contents

Protein chains

278 a.a.

217 a.a.

338 a.a.

60 a.a.

233 a.a.

Ligands

FLF ×2

PDB id:

8rql

Name:

Structural protein

Title:

Tas2r14 receptor bound to flufenamic acid and gustducin

Structure:

Taste receptor type 2 member 14. Chain: r. Synonym: t2r14,taste receptor family b member 1,trb1. Engineered: yes. Guanine nucleotide-binding protein g(t) subunit alpha-3. Chain: a. Synonym: gustducin alpha-3 chain. Engineered: yes. Other_details: mini g alpha gustducin protein,mini g alpha gustducin

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: tas2r14. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnat3. Gene: gnb1. Gene: gng2.

Authors:

D.Matzov,L.Peri,M.Niv,M.Shalev Benami

Key ref:

L.Peri et al. (2024). A bitter anti-Inflammatory drug binds at two distinct of a human bitter taste gpcr.. Nat commun, 15, 9991. PubMed id: 39557861

Date:

18-Jan-24 Release date: 27-Nov-24

Protein chain

Q9NYV8  (T2R14_HUMAN) -  Taste receptor type 2 member 14 from Homo sapiens

Seq: 317 a.a.

Struc: 278 a.a.

Protein chain

A8MTJ3  (GNAT3_HUMAN) -  Guanine nucleotide-binding protein G(t) subunit alpha-3 from Homo sapiens

Seq: 354 a.a.

Struc: 217 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 60 a.a.

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

* PDB and UniProt seqs differ at 55 residue positions (black crosses)