PDBsum entry 8pm2

Membrane protein

PDB id: 8pm2

Contents

Protein chains

229 a.a.

335 a.a.

55 a.a.

126 a.a.

261 a.a.

Ligands

Y01

8IA

PDB id:

8pm2

Name:

Membrane protein

Title:

Structure of the murine trace amine-associated receptor taar7f bound to n,n-dimethylcyclohexylamine (dmch) in complex with mini-gs trimeric g protein

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Expression_system_variant: codonplus(de3)-ril. Gene: gnb1. Expressed in: trichoplusia ni.

Authors:

A.Gusach,Y.Lee,P.C.Edwards,F.Huang,S.N.Weyand,C.G.Tate

Key ref:

A.Gusach et al. Molecular recognition of an aversive odorant by the m trace amine-Associated receptor taar7f.. Biorxiv, . PubMed id: 37461561

Date:

28-Jun-23 Release date: 09-Aug-23

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 229 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 335 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

Protein chain

Q5QD08  (TAA7F_MOUSE) -  Trace amine-associated receptor 7f from Mus musculus

Seq: 358 a.a.

Struc: 261 a.a.

* PDB and UniProt seqs differ at 54 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????