PDBsum entry 8pkm

Membrane protein

PDB id: 8pkm

Contents

Protein chains

215 a.a.

331 a.a.

51 a.a.

277 a.a.

Ligands

CLR

T7M

ZKV

PDB id:

8pkm

Name:

Membrane protein

Title:

Befiradol-bound serotonin 5-ht1a receptor - gi protein complex

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Gene: htr1a, adrb2rl1, adrbrl1.

Authors:

J.Schneider,P.Gmeiner,T.T.Hove,T.Rasmussen,B.Boettcher

Key ref:

B.Boettcher Discovery of a functionally selective serotonin 1a re agonist for the treatment of pain. To be published, . PubMed id: 40531992

Date:

27-Jun-23 Release date: 29-May-24

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 215 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 331 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 51 a.a.

Protein chain

P08908  (5HT1A_HUMAN) -  5-hydroxytryptamine receptor 1A from Homo sapiens

Seq: 422 a.a.

Struc: 277 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????