PDBsum entry 8kgk

Membrane protein

PDB id: 8kgk

Contents

Protein chains

256 a.a.

229 a.a.

339 a.a.

56 a.a.

126 a.a.

PDB id:

8kgk

Name:

Membrane protein

Title:

Cryo-em structure of the gpr61-gs complex

Structure:

G-protein coupled receptor 61. Chain: a. Synonym: biogenic amine receptor-like g-protein coupled receptor. Engineered: yes. Guanine nucleotide-binding protein g(olf) subunit alpha, guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: b. Synonym: adenylate cyclase-stimulating g alpha protein,olfactory type,adenylate cyclase-stimulating g alpha protein.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gpr61, balgr, gpcr3. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293f. Gene: gnal, gnas, gnas1, gsp. Gene: gnb1.

Authors:

Y.Nie,Z.Qiu,S.Zheng

Key ref:

Y.Nie et al. (2023). Specific binding of gpr174 by endogenous lysophosphatidylserine leads to high constitutive g s signaling.. Nat commun, 14, 5901. PubMed id: 37737235

Date:

19-Aug-23 Release date: 11-Oct-23

Protein chain

Q9BZJ8  (GPR61_HUMAN) -  G-protein coupled receptor 61 from Homo sapiens

Seq: 451 a.a.

Struc: 256 a.a.

Protein chain

P38405  (GNAL_HUMAN) -  Guanine nucleotide-binding protein G(olf) subunit alpha from Homo sapiens

Seq: 381 a.a.

Struc: 229 a.a.*

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 229 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

* PDB and UniProt seqs differ at 126 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain B: E.C.3.6.5.- - ?????