PDBsum entry 8jsr

Membrane protein

PDB id: 8jsr

Contents

Protein chains

282 a.a.

240 a.a.

340 a.a.

230 a.a.

57 a.a.

126 a.a.

Ligands

UYI

PDB id:

8jsr

Name:

Membrane protein

Title:

Cryo-em structure of the anamorelin-bound ghrelin receptor and gq complex

Structure:

Growth hormone secretagogue receptor type 1. Chain: r. Synonym: ghs-r,gh-releasing peptide receptor,ghrp,ghrelin receptor. Engineered: yes. Engineered g-alpha-q. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ghsr. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Mus musculus. Organism_taxid: 10090.

Authors:

D.Im,Y.Shimura,H.Asada,S.Iwata

Key ref:

Y.Shimura et al. The structure and function of the ghrelin receptor co for drug actions. Nat struct mol biol, . PubMed id: 39833471

Date:

20-Jun-23 Release date: 22-Jan-25

Protein chain

Q92847  (GHSR_HUMAN) -  Growth hormone secretagogue receptor type 1 from Homo sapiens

Seq: 366 a.a.

Struc: 282 a.a.

Protein chain

No UniProt id for this chain

Struc: 240 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 340 a.a.

Protein chain

No UniProt id for this chain

Struc: 230 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.