PDBsum entry 8jii

Membrane protein

PDB id: 8jii

Contents

Protein chains

340 a.a.

57 a.a.

226 a.a.

232 a.a.

289 a.a.

Ligands

NIO

CLR

IX8

Waters ×1

PDB id:

8jii

Name:

Membrane protein

Title:

Cryo-em structure of compound 9n and niacin bound ketone body receptor hcar2-gi signaling complex

Structure:

Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2. Chain: c. Synonym: g gamma-i.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gng2. Gene: gnai1. Mus musculus.

Authors:

C.Zhao,X.W.Tian,Y.Liu,L.Cheng,W.Yan,Z.H.Shao

Key ref:

C.Zhao et al. Biased allosteric activation of ketone body receptor suppresses inflammation.. Mol cell, . PubMed id: 37597514

Date:

26-May-23 Release date: 06-Sep-23

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 340 a.a.*

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 226 a.a.*

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Protein chain

Q8TDS4  (HCAR2_HUMAN) -  Hydroxycarboxylic acid receptor 2 from Homo sapiens

Seq: 363 a.a.

Struc: 289 a.a.

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain D: E.C.3.6.5.- - ?????