PDBsum entry 8jei

Membrane protein

PDB id: 8jei

Contents

Protein chains

216 a.a.

337 a.a.

56 a.a.

233 a.a.

285 a.a.

Ligands

CW3

PDB id:

8jei

Name:

Membrane protein

Title:

Cryo-em structure of the compuond 5c-hcar3-gi complex

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: c. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Gene: hcar3, gpr109b, hca3, hm74b, niacr2.

Authors:

Y.Fang,X.Pan

Key ref:

F.Ye et al. (2024). Structural basis for ligand recognition of the human hydroxycarboxylic acid receptor hcar3.. Cell rep, 43, 14895. PubMed id: 39427321 DOI: 10.1016/J.CELREP.2024.114895

Date:

15-May-23 Release date: 20-Nov-24

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 216 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 337 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

Protein chain

P49019  (HCAR3_HUMAN) -  Hydroxycarboxylic acid receptor 3 from Homo sapiens

Seq: 387 a.a.

Struc: 285 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)