PDBsum entry 8jd3

Membrane protein

PDB id: 8jd3

Contents

Protein chains

774 a.a.

763 a.a.

219 a.a.

336 a.a.

54 a.a.

Ligands

HZR

GLU ×2

CLR ×3

PEF

PDB id:

8jd3

Name:

Membrane protein

Title:

Cryo-em structure of gi1-bound mglu2-mglu3 heterodimer

Structure:

Metabotropic glutamate receptor 2. Chain: 2. Synonym: mglur2. Engineered: yes. Metabotropic glutamate receptor 3. Chain: 3. Synonym: mglur3. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: grm2, gprc1b, mglur2. Expressed in: mammal environmental sample. Expression_system_taxid: 1092587. Gene: grm3, gprc1c, mglur3. Gene: gnai1. Expressed in: baculovirus expression vector pfastbac1-hm.

Authors:

X.Wang,M.Wang,T.Xu,Y.Feng,S.Han,S.Lin,Q.Zhao,B.Wu

Key ref:

X.Wang et al. Structural insights into dimerization and activation mglu2-Mglu3 and mglu2-Mglu4 heterodimers.. Cell res, . PubMed id: 37286794

Date:

12-May-23 Release date: 21-Jun-23

Protein chain

Q14416  (GRM2_HUMAN) -  Metabotropic glutamate receptor 2 from Homo sapiens

Seq: 872 a.a.

Struc: 774 a.a.

Protein chain

Q14832  (GRM3_HUMAN) -  Metabotropic glutamate receptor 3 from Homo sapiens

Seq: 879 a.a.

Struc: 763 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 219 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 336 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 54 a.a.

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????