PDBsum entry 8izb

Signaling protein

PDB id: 8izb

Contents

Protein chains

235 a.a.

342 a.a.

57 a.a.

128 a.a.

283 a.a.

Ligands

UBL-SER

CLR ×2

PDB id:

8izb

Name:

Signaling protein

Title:

Lysophosphatidylserine receptor gpr174-gs complex

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Synthetic construct.

Authors:

W.Gong,G.Liu,X.Li,X.Zhang

Key ref:

W.Gong et al. Structural mechanisms of ligand binding and signaling lysophosphatidylserine receptors. To be published, . PubMed id: 38048360

Date:

06-Apr-23 Release date: 01-Nov-23

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 235 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 342 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

Protein chain

Q9BXC1  (GP174_HUMAN) -  Probable G-protein coupled receptor 174 from Homo sapiens

Seq: 333 a.a.

Struc: 283 a.a.

* PDB and UniProt seqs differ at 11 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????