PDBsum entry 8hmv

Membrane protein

PDB id: 8hmv

Contents

Protein chains

274 a.a.

227 a.a.

338 a.a.

57 a.a.

126 a.a.

PDB id:

8hmv

Name:

Membrane protein

Title:

Structure of gpr21-gs complex

Structure:

Probable g-protein coupled receptor 21. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: c. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Mutation: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gpr21. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnas, gnas1, gsp. Gene: gnb1. Gene: gng2.

Authors:

T.S.Wong,W.Gao

Key ref:

T.S.Wong et al. (2023). Cryo-Em structure of orphan g protein-Coupled recepto gpr21.. Medcomm (2020), 4, e205. PubMed id: 36721851

Date:

05-Dec-22 Release date: 01-Mar-23

Protein chain

Q99679  (GPR21_HUMAN) -  Probable G-protein coupled receptor 21 from Homo sapiens

Seq: 349 a.a.

Struc: 274 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 227 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain C: E.C.3.6.5.- - ?????