PDBsum entry 8gdb

Signaling protein

PDB id: 8gdb

Contents

Protein chains

231 a.a.

339 a.a.

58 a.a.

126 a.a.

283 a.a.

Ligands

P2E

PDB id:

8gdb

Name:

Signaling protein

Title:

Cryo-em structure of the prostaglandin e2 receptor 4 coupled to g protein

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590. Gene: gnb1. Gene: mrhifer1_005810. Lama glama.

Authors:

H.Shenming,X.Mengyao,L.Lei,M.Jianqiang,S.Jinpeng

Key ref:

S.M.Huang et al. (2023). Single hormone or synthetic agonist induces g s /g i coupling selectivity of ep receptors via distinct bin modes and propagating paths.. Proc natl acad sci usa, 120, 29120. PubMed id: 37478163

Date:

03-Mar-23 Release date: 10-Jan-24

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 231 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 58 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

Protein chain

P35408  (PE2R4_HUMAN) -  Prostaglandin E2 receptor EP4 subtype from Homo sapiens

Seq: 488 a.a.

Struc: 283 a.a.

* PDB and UniProt seqs differ at 8 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????