PDBsum entry 7x2c

Signaling protein

PDB id: 7x2c

Contents

Protein chains

279 a.a.

229 a.a.

339 a.a.

56 a.a.

128 a.a.

Ligands

CLR

G3C ×2

PDB id:

7x2c

Name:

Signaling protein

Title:

Cryo-em structure of the fenoldopam-bound d1 dopamine receptor and mini-gs complex

Structure:

D(1a) dopamine receptor. Chain: f. Synonym: dopamine d1 receptor. Engineered: yes. Guanine nucleotide-binding protein g(s) subunit alpha isoforms short, isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: drd1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: gnas. Gene: gnb1. Expressed in: trichoplusia ni.

Authors:

X.Teng,S.Zheng

Key ref:

X.Teng et al. (2022). Ligand recognition and biased agonism of the d1 dopam receptor.. Nat commun, 13, 3186. PubMed id: 35676276

Date:

25-Feb-22 Release date: 29-Jun-22

Protein chain

P21728  (DRD1_HUMAN) -  D(1A) dopamine receptor from Homo sapiens

Seq: 446 a.a.

Struc: 279 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 229 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

* PDB and UniProt seqs differ at 53 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????