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UniProt functional annotation for P21728 | ||
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| UniProt code: P21728. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
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| Subunit: | |
Interacts with DNAJC14 via its C-terminus (By similarity). Interacts with DRD2 (By similarity). {ECO:0000250|UniProtKB:P18901, ECO:0000250|UniProtKB:Q61616}. |
| Subcellular location: | |
Cell membrane {ECO:0000250|UniProtKB:P18901}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18901}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P18901}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18901}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q61616}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q61616}. Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. {ECO:0000250|UniProtKB:P18901}. |
| Tissue specificity: | |
Detected in caudate, nucleus accumbens and in the olfactory tubercle. {ECO:0000269|PubMed:2144334}. |
| Similarity: | |
Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
Annotations taken from UniProtKB at the EBI.