PDBsum entry 7omf

Splicing

PDB id: 7omf

Contents

Protein chains

869 a.a.

65 a.a.

842 a.a.

93 a.a.

Ligands

T2W

SCN

Metals

_ZN ×3

PDB id:

7omf

Name:

Splicing

Title:

Structure of a minimal sf3b core in complex with sudemycin d6 (form i)

Structure:

Splicing factor 3b subunit 3. Chain: a. Synonym: pre-mRNA-splicing factor sf3b 130 kda subunit,sf3b130, staf130,spliceosome-associated protein 130,sap 130. Engineered: yes. Splicing factor 3b subunit 5. Chain: b. Synonym: sf3b5,pre-mRNA-splicing factor sf3b 10 kda subunit. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: sf3b3, kiaa0017, sap130. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: sf3b5, sf3b10. Gene: sf3b1, sap155. Gene: phf5a.

Resolution:

3.00Å R-factor: 0.234 R-free: 0.266

Authors:

C.Cretu,V.Pena

Key ref:

C.Cretu et al. (2021). Structural basis of intron selection by u2 snrnp in t presence of covalent inhibitors.. Nat commun, 12, 4491. PubMed id: 34301950

Date:

21-May-21 Release date: 04-Aug-21

Protein chain

Q15393  (SF3B3_HUMAN) -  Splicing factor 3B subunit 3 from Homo sapiens

Seq: 1217 a.a.

Struc: 869 a.a.

Protein chain

Q9BWJ5  (SF3B5_HUMAN) -  Splicing factor 3B subunit 5 from Homo sapiens

Seq: 86 a.a.

Struc: 65 a.a.

Protein chain

O75533  (SF3B1_HUMAN) -  Splicing factor 3B subunit 1 from Homo sapiens

Seq: 1304 a.a.

Struc: 842 a.a.

Protein chain

Q7RTV0  (PHF5A_HUMAN) -  PHD finger-like domain-containing protein 5A from Homo sapiens

Seq: 110 a.a.

Struc: 93 a.a.