PDBsum entry 7duq

Biosynthetic protein

PDB id: 7duq

Contents

Protein chains

30 a.a.

384 a.a.

240 a.a.

338 a.a.

56 a.a.

126 a.a.

Ligands

HNO

CLR ×7

PDB id:

7duq

Name:

Biosynthetic protein

Title:

Cryo-em structure of the compound 2 and glp-1-bound human glp-1 receptor-gs complex

Structure:

Glucagon-like peptide 1. Chain: p. Engineered: yes. Glucagon-like peptide 1 receptor. Chain: r. Synonym: glp-1r. Engineered: yes. Guanine nucleotide-binding protein g(s) subunit alpha isoforms short.

Source:

Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: glp1r. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnas, gnas1, gsp. Rattus norvegicus.

Authors:

Z.Cong,L.Chen,H.Ma,Q.Zhou,X.Zou,C.Ye,A.Dai,Q.Liu,W.Huang,X.Sun, X.Wang,P.Xu,L.Zhao,T.Xia,W.Zhong,D.Yang,H.E.Xu,Y.Zhang,M.Wang

Key ref:

Z.Cong et al. (2021). Molecular insights into ago-Allosteric modulation of human glucagon-Like peptide-1 receptor.. Nat commun, 12, 3763. PubMed id: 34145245

Date:

11-Jan-21 Release date: 14-Jul-21

Protein chain

P01275  (GLUC_HUMAN) -  Pro-glucagon from Homo sapiens

Seq: 180 a.a.

Struc: 30 a.a.

Protein chain

P43220  (GLP1R_HUMAN) -  Glucagon-like peptide 1 receptor from Homo sapiens

Seq: 463 a.a.

Struc: 384 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 240 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

* PDB and UniProt seqs differ at 8 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????