PDBsum entry 7yu6

Membrane protein

PDB id: 7yu6

Contents

Protein chains

338 a.a.

222 a.a.

54 a.a.

290 a.a.

232 a.a.

Ligands

K6L

PDB id:

7yu6

Name:

Membrane protein

Title:

Human lysophosphatidic acid receptor 1-gi complex bound to ono- 0740556, state2

Structure:

Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes.

Source:

Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: gnb1. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590. Homo sapiens. Human. Organism_taxid: 9606.

Authors:

H.Akasaka,W.Shihoya,O.Nureki

Key ref:

H.Akasaka et al. (2022). Structure of the active g i -Coupled human lysophosph acid receptor 1 complexed with a potent agonist.. Nat commun, 13, 5417. PubMed id: 36109516

Date:

16-Aug-22 Release date: 05-Oct-22

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 222 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 54 a.a.

Protein chain

Q92633  (LPAR1_HUMAN) -  Lysophosphatidic acid receptor 1 from Homo sapiens

Seq: 364 a.a.

Struc: 290 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????