PDBsum entry 7xk9

Membrane protein

PDB id: 7xk9

Contents

Protein chains

454 a.a.

120 a.a.

Ligands

GJ6

Metals

_NA

PDB id:

7xk9

Name:

Membrane protein

Title:

Structure of human beta2 adrenergic receptor bound to constrained isoproterenol

Structure:

Endolysin,beta-2 adrenergic receptor. Chain: a. Synonym: lysis protein,lysozyme,muramidase,beta-2 adrenoreceptor, beta-2 adrenoceptor. Engineered: yes. Mutation: yes. Other_details: chimera protein. Camelid antibody fragment. Chain: b.

Source:

Enterobacteria phage t4, homo sapiens. Bacteriophage t4, human. Organism_taxid: 10665, 9606. Gene: adrb2, adrb2r, b2ar. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606.

Resolution:

3.40Å R-factor: 0.227 R-free: 0.261

Authors:

X.Xu,J.Shonberg,J.Kaindl,M.Clark,A.Stobel,L.Maul,D.Mayer,H.Hubner, A.Venkatakrishnan,R.Dror,B.K.Kobilka,R.Sunahara,X.Liu,P.Gmeiner

Key ref:

X.Xu et al. Structure of human beta2 adrenergic receptor bound to constrained isoproterenol. To be published, . PubMed id: 37059717

Date:

19-Apr-22 Release date: 26-Apr-23

Protein chain

P00720  (ENLYS_BPT4) -  Endolysin from Enterobacteria phage T4

Seq: 164 a.a.

Struc: 454 a.a.*

Protein chain

P07550  (ADRB2_HUMAN) -  Beta-2 adrenergic receptor from Homo sapiens

Seq: 413 a.a.

Struc: 454 a.a.*

Protein chain

No UniProt id for this chain

Struc: 120 a.a.

* PDB and UniProt seqs differ at 40 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.2.1.17 - lysozyme.
• Reaction: Hydrolysis of the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of the prokaryotes cell walls.