PDBsum entry 7w41

Membrane protein

PDB id: 7w41

Contents

Protein chain

484 a.a.

Ligands

8B8

PDB id:

7w41

Name:

Membrane protein

Title:

Crystal structure of human gastrin releasing peptide receptor in complex with the antagonist pd176252

Structure:

Gastrin-releasing peptide receptor,glga glycogen synthase. Chain: a. Synonym: grp-r,grp-preferring bombesin receptor,glycogen synthase. Engineered: yes. Mutation: yes

Source:

Homo sapiens, pyrococcus abyssi ge5. Human. Organism_taxid: 9606, 272844. Strain: ge5 / orsay. Gene: grpr, pab2292. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.95Å R-factor: 0.280 R-free: 0.321

Authors:

S.Peng,Y.Zhan,H.Zhang

Key ref:

S.Peng et al. (2023). Structures of human gastrin-Releasing peptide recepto bound to antagonist and agonist for cancer and itch t. Proc natl acad sci usa, 120, 30120. PubMed id: 36724251

Date:

26-Nov-21 Release date: 22-Feb-23

Protein chain

P30550  (GRPR_HUMAN) -  Gastrin-releasing peptide receptor from Homo sapiens

Seq: 384 a.a.

Struc: 484 a.a.*

Protein chain

Q9V2J8  (Q9V2J8_PYRAB) -  Glycogen synthase from Pyrococcus abyssi (strain GE5 / Orsay)

Seq: 437 a.a.

Struc: 484 a.a.*

* PDB and UniProt seqs differ at 390 residue positions (black crosses)