PDBsum entry 7vvm

Signaling protein

PDB id: 7vvm

Contents

Protein chains

230 a.a.

335 a.a.

54 a.a.

128 a.a.

32 a.a.

354 a.a.

PDB id:

7vvm

Name:

Signaling protein

Title:

Pth-bound human pth1r in complex with gs (class3)

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Rattus norvegicus. Norway rat.

Authors:

K.Kobayashi,T.Kusakizako,H.Miyauchi,A.Tomita,K.Kobayashi,W.Shihoya, K.Yamashita,T.Nishizawa,H.E.Kato,O.Nureki

Key ref:

K.Kobayashi et al. Endogenous ligand-Bound the human pth receptor in com with gs. To be published, . PubMed id: 35932760

Date:

06-Nov-21 Release date: 03-Aug-22

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 230 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 335 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 54 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

Protein chain

P01270  (PTHY_HUMAN) -  Parathyroid hormone from Homo sapiens

Seq: 115 a.a.

Struc: 32 a.a.

Protein chain

Q03431  (PTH1R_HUMAN) -  Parathyroid hormone/parathyroid hormone-related peptide receptor from Homo sapiens

Seq: 593 a.a.

Struc: 354 a.a.

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????