PDBsum entry 7um6

Membrane protein

PDB id: 7um6

Contents

Protein chains

258 a.a.

214 a.a.

338 a.a.

54 a.a.

230 a.a.

Ligands

H8G

PDB id:

7um6

Name:

Membrane protein

Title:

Cryoem structure of go-coupled 5-ht5ar in complex with lisuride

Structure:

5-hydroxytryptamine receptor 5a. Chain: a. Synonym: 5-ht-5,5-ht-5a,5-ht5a,serotonin receptor 5a. Engineered: yes. Mutation: yes. Minigo protein. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: htr5a. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Mus musculus.

Authors:

S.Zhang,J.F.Fay,B.L.Roth

Key ref:

S.Zhang et al. Inactive and active state structures template selecti tools for the human 5-Ht5a receptor. Nat struct mol biol, . PubMed id: 35835867

Date:

06-Apr-22 Release date: 20-Jul-22

Protein chain

P47898  (5HT5A_HUMAN) -  5-hydroxytryptamine receptor 5A from Homo sapiens

Seq: 357 a.a.

Struc: 258 a.a.*

Protein chain

No UniProt id for this chain

Struc: 214 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 54 a.a.

Protein chain

No UniProt id for this chain

Struc: 230 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)