PDBsum entry 7tyi

Membrane protein

PDB id: 7tyi

Contents

Protein chains

228 a.a.

339 a.a.

55 a.a.

128 a.a.

38 a.a.

367 a.a.

Ligands

PLM ×10

NAG ×2

PDB id:

7tyi

Name:

Membrane protein

Title:

Calcitonin receptor in complex with gs and rat amylin peptide, ct-like state

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnb1. Gene: gng2. Lama glama.

Authors:

J.Cao,M.J.Belousoff,R.M.Johnson,D.L.Wootten,P.M.Sexton

Key ref:

J.Cao et al. A structural basis for amylin receptor phenotype. To be published, . PubMed id: 35324283

Date:

13-Feb-22 Release date: 30-Mar-22

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 228 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

Protein chain

P12969  (IAPP_RAT) -  Islet amyloid polypeptide from Rattus norvegicus

Seq: 93 a.a.

Struc: 38 a.a.*

Protein chain

P30988  (CALCR_HUMAN) -  Calcitonin receptor from Homo sapiens

Seq: 474 a.a.

Struc: 367 a.a.

* PDB and UniProt seqs differ at 9 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????