UniProt functional annotation for P30988



	UniProt functional annotation for P30988

UniProt code: P30988.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

Function: [Isoform 2]: Receptor for calcitonin but is unable to couple to G proteins and activate adenylyl cyclase (PubMed:7476993). Does not undergo receptor internalization following ligand binding (PubMed:7476993). {ECO:0000269|PubMed:7476993}.

Subunit: Interacts with GPRASP2. {ECO:0000269|PubMed:15086532}.

Subcellular location: Cell membrane; Multi-pass membrane protein.

Polymorphism: Genetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disruption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.

Similarity: Belongs to the G-protein coupled receptor 2 family. {ECO:0000305}.

Sequence caution: Sequence=AAA35640.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.



Function:		[Isoform 2]: Receptor for calcitonin but is unable to couple to G proteins and activate adenylyl cyclase (PubMed:7476993). Does not undergo receptor internalization following ligand binding (PubMed:7476993). {ECO:0000269\|PubMed:7476993}.


Subunit:		Interacts with GPRASP2. {ECO:0000269\|PubMed:15086532}.
Subcellular location:		Cell membrane; Multi-pass membrane protein.
Polymorphism:		Genetic variations in CALCR may be correlated with bone mineral density (BMD). Low BMD is a risk factor for osteoporotic fracture. Osteoporosis is characterized by reduced bone mineral density, disruption of bone microarchitecture, and the alteration of the amount and variety of non-collagenous proteins in bone. Osteoporotic bones are more at risk of fracture.
Similarity:		Belongs to the G-protein coupled receptor 2 family. {ECO:0000305}.
Sequence caution:		Sequence=AAA35640.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};