PDBsum entry 7knu

Signaling protein

PDB id: 7knu

Contents

Protein chains

115 a.a.

11 a.a.

341 a.a.

PDB id:

7knu

Name:

Signaling protein

Title:

Cryoem structure of the cgrp receptor with bound cgrp peptide in a detergent micelle

Structure:

Receptor activity-modifying protein 1. Chain: e. Synonym: calcitonin-receptor-like receptor activity-modifying protein 1,crlr activity-modifying protein 1. Engineered: yes. Calcitonin gene-related peptide 1. Chain: p. Synonym: alpha-type cgrp,calcitonin gene-related peptide i,cgrp-i. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ramp1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Synthetic: yes. Gene: calcrl, cgrpr. Expression_system_taxid: 7111

Authors:

M.J.Belousoff,R.Danev

Key ref:

t.m.josephs et al. (2021). Structure and dynamics of the CGRP receptor in apo and peptide-bound forms. Science, 0, . PubMed id: 33602864

Date:

06-Nov-20 Release date: 24-Feb-21

Protein chain

O60894  (RAMP1_HUMAN) -  Receptor activity-modifying protein 1 from Homo sapiens

Seq: 148 a.a.

Struc: 115 a.a.

Protein chain

P06881  (CALCA_HUMAN) -  Calcitonin gene-related peptide 1 from Homo sapiens

Seq: 128 a.a.

Struc: 11 a.a.

Protein chain

Q16602  (CALRL_HUMAN) -  Calcitonin gene-related peptide type 1 receptor from Homo sapiens

Seq: 461 a.a.

Struc: 341 a.a.

Science 0: (2021)

PubMed id: 33602864

Structure and dynamics of the CGRP receptor in apo and peptide-bound forms.

t.m.josephs, m.j.belousoff, y.-l.liang, s.j.piper, j.cao, d.j.garama, k.leach, k.j.gregory, a.christopoulos, d.l.har.danev, d.wootten, p.m.sexton.

ABSTRACT

No abstract given.