PDBsum entry 7ki0

Membrane protein

PDB id: 7ki0

Contents

Protein chains

209 a.a.

338 a.a.

56 a.a.

126 a.a.

30 a.a.

384 a.a.

Ligands

WF1

Waters ×79

PDB id:

7ki0

Name:

Membrane protein

Title:

Semaglutide-bound glucagon-like peptide-1 (glp-1) receptor in complex with gs protein

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnb1. Gene: gng2. Lama glama.

Authors:

X.Zhang,M.J.Belousoff,R.Danev,P.M.Sexton,D.Wootten

Key ref:

X.Zhang et al. (2021). Structure and dynamics of semaglutide- And taspoglutide-Bound glp-1r-Gs complexes.. Cell rep, 36, 09374. PubMed id: 34260945

Date:

22-Oct-20 Release date: 04-Aug-21

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 209 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

Protein chain

P01275  (GLUC_HUMAN) -  Pro-glucagon from Homo sapiens

Seq: 180 a.a.

Struc: 30 a.a.*

Protein chain

P43220  (GLP1R_HUMAN) -  Glucagon-like peptide 1 receptor from Homo sapiens

Seq: 463 a.a.

Struc: 384 a.a.*

* PDB and UniProt seqs differ at 42 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????