PDBsum entry 5upy

Oxidoreductase

PDB id: 5upy

Contents

Protein chain

350 a.a.

Ligands

IMP

Q21

GOL ×3

EDO ×3

Metals

_CL

Waters ×104

PDB id:

5upy

Name:

Oxidoreductase

Title:

Crystal structure of the catalytic domain of the inosine monophosphate dehydrogenase from listeria monocytogenes in the complex with imp and q21

Structure:

Inosine-5'-monophosphate dehydrogenase. Chain: a. Synonym: impdh. Engineered: yes

Source:

Listeria monocytogenes serovar 1/2a (strain atcc baa-679 / egd-e). Organism_taxid: 169963. Strain: atcc baa-679 / egd-e. Gene: guab. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.35Å R-factor: 0.166 R-free: 0.209

Authors:

Y.Kim,M.Makowska-Grzyska,J.Osipiuk,W.F.Anderson,A.Joachimiak,Center For Structural Genomics Of Infectious Diseases (Csgid)

Key ref:

Y.Kim et al. Crystal structure of the catalytic domain of the inos monophosphate dehydrogenase from listeria monocytogen the complex with imp and q21. To be published, .

Date:

04-Feb-17 Release date: 05-Apr-17

Protein chain

Q926Y9  (Q926Y9_LISMO) -  Inosine-5'-monophosphate dehydrogenase from Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

Seq: 488 a.a.

Struc: 350 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.1.1.1.205 - Imp dehydrogenase.
• Pathway: AMP and GMP Biosynthesis
• Reaction: IMP + NAD⁺ + H2O = XMP + NADH + H⁺

IMP + NAD(+) (Bound ligand (Het Group name = IMP) corresponds exactly) + H2O = XMP + NADH + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site