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PDBsum entry 5cbk
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Signaling protein
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PDB id
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5cbk
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References listed in PDB file
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Key reference
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Title
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Structure-Function analysis identifies highly sensitive strigolactone receptors in striga.
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Authors
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S.Toh,
D.Holbrook-Smith,
P.J.Stogios,
O.Onopriyenko,
S.Lumba,
Y.Tsuchiya,
A.Savchenko,
P.Mccourt.
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Ref.
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Science, 2015,
350,
203-207.
[DOI no: ]
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PubMed id
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Abstract
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Strigolactones are naturally occurring signaling molecules that affect plant
development, fungi-plant interactions, and parasitic plant infestations. We
characterized the function of 11 strigolactone receptors from the parasitic
plant Striga hermonthica using chemical and structural biology. We found a clade
of polyspecific receptors, including one that is sensitive to picomolar
concentrations of strigolactone. A crystal structure of a highly sensitive
strigolactone receptor from Striga revealed a larger binding pocket than that of
the Arabidopsis receptor, which could explain the increased range of
strigolactone sensitivity. Thus, the sensitivity of Striga to strigolactones
from host plants is driven by receptor sensitivity. By expressing strigolactone
receptors in Arabidopsis, we developed a bioassay that can be used to identify
chemicals and crops with altered strigolactone levels.
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