PDBsum entry 4zv7

Hydrolase

PDB id: 4zv7

Contents

Protein chain

317 a.a.

Ligands

NAG-NAG

Waters ×332

References listed in PDB file

Key reference

• Title: Crystal and molecular structure of hexagonal form of lipase b from candida antarctica.
• Authors: P.Strzelczyk, G.D.Bujacz, P.Kiełbasiński, J.Błaszczyk.
• Ref.: Acta Biochim Pol, 2016, 63, 1065-109. [DOI no: 10.18388/abp.2015_1065]
• PubMed id: 26716135

Abstract

During crystallization screenings of commercially available hydrolytic enzymes, the new, hexagonal crystal form of CAL-B, has been discovered and hereby reported. The NAG molecules, which were closing the glycosylation site in the orthorhombic form, in hexagonal structure make the glycosylation site open. It is unknown whether the opening and closing of the glycosylation site by the 'lid' NAG molecules, could be related to the opening and closing of the active center of the enzyme upon substrate binding and product release.