PDBsum entry 4zcw

Lyase/lyase inhibitor

PDB id: 4zcw

Contents

Protein chains

433 a.a.

Ligands

4NG ×2

Metals

_MG ×4

Waters ×595

PDB id:

4zcw

Name:

Lyase/lyase inhibitor

Title:

Structure of human enolase 2 in complex with sf2312

Structure:

Gamma-enolase. Chain: a, b. Synonym: 2-phospho-d-glycerate hydro-lyase, enolase 2, neural enolase, neuron-specific enolase, nse. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: eno2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

Resolution:

1.99Å R-factor: 0.159 R-free: 0.202

Authors:

P.G.Leonard,D.Maxwell,B.Czako,F.L.Muller

Key ref:

P.G.Leonard et al. (2016). SF2312 is a natural phosphonate inhibitor of enolase. Nat Chem Biol, 12, 1053-1058. PubMed id: 27723749 DOI: 10.1038/nchembio.2195

Date:

16-Apr-15 Release date: 20-Jul-16

Protein chains

P09104  (ENOG_HUMAN) -  Gamma-enolase from Homo sapiens

Seq: 434 a.a.

Struc: 433 a.a.

Enzyme reactions

• Enzyme class: E.C.4.2.1.11 - phosphopyruvate hydratase.
• Reaction: (2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O
• Cofactor: Mg(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Key reference

DOI no: 10.1038/nchembio.2195

Nat Chem Biol 12:1053-1058 (2016)

PubMed id: 27723749

SF2312 is a natural phosphonate inhibitor of enolase.

P.G.Leonard, N.Satani, D.Maxwell, Y.H.Lin, N.Hammoudi, Z.Peng, F.Pisaneschi, T.M.Link, G.R.Lee, D.Sun, B.A.Prasad, M.E.Di Francesco, B.Czako, J.M.Asara, Y.A.Wang, W.Bornmann, R.A.DePinho, F.L.Muller.

ABSTRACT

No abstract given.