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PDBsum entry 4y8h
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Top Page protein ligands metals Protein-protein interface(s) tunnels links
Tunnel analysis for: 4y8h calculated with MOLE 2.0 PDB id
4y8h
Tunnels calculated on whole structure Tunnels calculated excluding ligands
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3 tunnels, coloured by tunnel radius 115 tunnels, coloured by tunnel radius 115 tunnels, coloured as in
list below
Tunnels are interior spaces connected with the protein surrounding. Only channels longer than 15 Å are shown.
Tunnels
Free R
Length
HPathy
HPhob
Polar
Rel Mut
Residue..type
Ligands
Radius
1 1.15 2.33 98.0 -1.12 -0.17 14.8 79 6 7 9 9 11 2 0  ACE 2 f AZI 1 h ACE 2 h
2 1.32 1.78 102.5 -1.44 -0.35 15.6 81 7 7 10 7 8 3 0  ACE 2 f AZI 1 h ACE 2 h
3 1.27 1.75 103.2 -1.53 -0.32 15.1 82 7 7 11 7 9 3 0  AZI 1 c ACE 2 c AZI 1 e ACE 2 e
4 1.29 1.80 105.0 -1.61 -0.38 14.8 83 7 7 12 6 9 3 0  AZI 1 c ACE 2 c AZI 1 e ACE 2 e
5 1.32 1.77 107.0 -1.73 -0.40 15.5 83 7 7 11 6 9 3 0  ACE 2 f AZI 1 h ACE 2 h
6 1.28 1.78 110.0 -1.26 -0.39 13.1 85 8 4 10 7 4 1 0  AZI 1 h ACE 2 h
7 1.30 1.73 111.9 -1.37 -0.38 12.8 85 8 4 10 7 5 1 0  AZI 1 e ACE 2 e
8 1.28 1.78 116.1 -1.23 -0.39 12.9 86 8 4 11 7 4 1 0  AZI 1 h ACE 2 h
9 1.31 1.74 118.0 -1.37 -0.41 12.7 86 8 4 11 7 5 1 0  AZI 1 e ACE 2 e
10 1.16 2.30 120.4 -1.04 -0.23 13.7 82 8 5 10 9 9 0 0  AZI 1 h ACE 2 h
11 1.17 1.60 125.0 -1.34 -0.33 17.0 84 7 11 11 9 9 1 0  ACE 2 f AZI 1 h ACE 2 h
12 1.17 2.29 126.6 -1.02 -0.24 13.7 83 8 5 11 9 9 0 0  AZI 1 h ACE 2 h
13 1.28 1.79 125.2 -2.12 -0.45 21.6 85 13 4 10 4 3 2 0  AZI 1 h ACE 2 h
14 1.31 1.77 126.6 -1.83 -0.32 18.9 81 13 3 11 6 6 2 0  AZI 1 h ACE 2 h
15 1.22 2.21 129.9 -1.21 -0.22 13.9 81 7 7 13 9 11 2 0  AZI 1 h ACE 2 h
16 1.21 1.59 129.5 -1.68 -0.52 18.1 86 8 11 12 7 6 2 0  ACE 2 f AZI 1 h ACE 2 h
17 1.34 1.76 128.8 -1.79 -0.33 17.4 82 13 3 13 5 8 1 1  AZI 1 e ACE 2 e
18 1.34 1.76 129.4 -2.37 -0.40 23.5 82 15 4 11 4 6 1 0  AZI 1 e ACE 2 e
19 1.27 1.78 129.6 -2.38 -0.49 20.9 86 13 4 11 3 4 2 0  AZI 1 h ACE 2 h
20 1.31 1.76 131.0 -2.05 -0.36 18.4 83 13 3 12 5 7 2 0  AZI 1 h ACE 2 h
21 1.27 1.78 132.1 -1.80 -0.53 18.0 86 9 11 13 6 7 3 0  AZI 1 c ACE 2 c AZI 1 e ACE 2 e
22 1.28 1.80 130.5 -1.89 -0.38 17.1 83 13 3 14 4 8 1 1  AZI 1 e ACE 2 e
23 1.28 1.80 130.6 -2.27 -0.41 23.5 82 15 4 12 4 5 1 0  AZI 1 h ACE 2 h
24 1.28 1.80 131.1 -2.45 -0.43 23.1 83 15 4 12 3 6 1 0  AZI 1 e ACE 2 e
25 1.31 1.79 135.1 -2.46 -0.44 23.0 83 15 4 13 3 6 1 0  AZI 1 h ACE 2 h
26 1.18 2.17 137.1 -1.43 -0.15 17.8 79 13 4 11 8 11 1 0  AZI 1 h ACE 2 h
27 1.29 1.80 135.1 -2.00 -0.42 19.1 87 13 1 15 5 5 1 0  AZI 1 h ACE 2 h
28 1.20 2.29 135.7 -1.65 -0.23 20.6 81 13 5 10 6 9 1 0  AZI 1 h ACE 2 h
29 1.35 1.78 135.3 -2.05 -0.36 18.3 83 10 2 13 5 7 1 0  AZI 1 e ACE 2 e
30 1.29 1.79 137.1 -2.11 -0.41 17.7 85 10 2 14 4 7 1 0  AZI 1 e ACE 2 e
31 1.31 1.80 138.4 -1.88 -0.43 17.8 86 12 5 14 5 4 1 0  AZI 1 h ACE 2 h
32 1.34 1.78 138.2 -1.79 -0.35 18.3 83 14 3 11 6 5 2 0  AZI 1 h ACE 2 h
33 1.31 1.78 139.4 -2.20 -0.45 19.1 86 13 3 15 5 6 1 0  AZI 1 e ACE 2 e
34 1.22 2.30 141.2 -1.83 -0.24 22.1 79 15 5 12 6 10 0 0  AZI 1 h ACE 2 h
35 1.29 1.79 139.1 -1.97 -0.38 18.4 81 11 3 13 5 8 2 0  AZI 1 h ACE 2 h
36 1.34 1.78 139.5 -2.23 -0.45 18.6 88 13 1 16 4 6 1 0  AZI 1 h ACE 2 h
37 1.28 1.30 140.8 -1.11 -0.26 13.4 83 12 1 13 8 6 2 0  AZI 1 h ACE 2 h
38 1.31 1.75 140.9 -1.86 -0.31 18.2 82 14 3 11 6 6 2 0  AZI 1 e ACE 2 e
39 1.34 1.43 141.2 -2.26 -0.48 18.7 87 13 3 16 4 6 1 0  AZI 1 e ACE 2 e
40 1.29 1.34 144.3 -1.25 -0.24 14.0 83 12 1 13 8 7 2 0  AZI 1 e ACE 2 e
41 1.35 1.79 141.5 -2.06 -0.43 21.9 85 17 4 12 6 5 2 0  AZI 1 h ACE 2 h
42 1.31 1.78 142.6 -1.97 -0.40 17.4 84 14 3 12 5 6 2 0  AZI 1 h ACE 2 h
43 1.35 1.78 142.9 -2.11 -0.46 18.2 87 12 5 15 4 5 1 0  AZI 1 h ACE 2 h
44 1.35 1.79 142.3 -2.11 -0.44 20.6 83 13 5 10 4 5 1 0  AZI 1 h ACE 2 h
45 1.34 1.78 142.7 -1.99 -0.38 17.7 84 14 3 12 5 6 2 0  AZI 1 e ACE 2 e
46 1.30 1.78 143.1 -2.22 -0.45 22.6 85 17 4 12 6 6 2 0  AZI 1 e ACE 2 e
47 1.23 1.24 146.2 -2.16 -0.39 22.6 83 14 6 10 6 5 2 0  AZI 1 e ACE 2 e
48 1.34 1.77 143.5 -2.15 -0.40 18.2 83 11 3 14 4 9 2 0  AZI 1 h ACE 2 h
49 1.32 1.47 145.3 -1.38 -0.30 13.9 84 12 1 14 7 7 2 0  AZI 1 h ACE 2 h
50 1.30 1.78 144.6 -2.32 -0.46 21.9 83 14 5 11 4 6 1 0  AZI 1 e ACE 2 e
51 1.28 1.75 145.7 -2.03 -0.44 18.6 86 14 5 14 5 5 1 0  AZI 1 e ACE 2 e
52 1.27 1.77 145.0 -1.87 -0.37 17.9 82 13 4 14 7 4 2 0  AZI 1 h ACE 2 h
53 1.30 1.76 145.6 -2.08 -0.38 18.4 82 13 4 14 7 6 2 0  AZI 1 e ACE 2 e
54 1.34 1.78 146.0 -1.33 -0.28 13.7 84 12 1 14 7 7 2 0  AZI 1 e ACE 2 e
55 1.23 2.32 145.6 -1.61 -0.24 18.8 84 13 2 15 7 10 0 0  AZI 1 h ACE 2 h
56 1.27 1.76 144.0 -1.85 -0.40 19.2 85 14 5 13 7 6 1 0  AZI 1 h ACE 2 h
57 1.33 1.78 145.9 -2.25 -0.46 21.5 86 17 4 13 5 6 2 0  AZI 1 h ACE 2 h
58 1.33 1.78 146.8 -1.52 -0.29 17.4 79 12 4 11 8 6 3 0  AZI 1 h ACE 2 h
59 1.33 1.78 146.0 -1.95 -0.37 20.1 84 14 5 13 7 7 1 0  AZI 1 e ACE 2 e
60 1.34 1.78 146.4 -2.37 -0.50 21.2 84 14 5 11 3 6 1 0  AZI 1 e ACE 2 e
61 1.34 1.78 144.9 -2.31 -0.48 22.4 86 17 4 13 5 6 2 0  AZI 1 e ACE 2 e
62 1.33 1.78 146.7 -2.07 -0.43 21.2 85 14 6 12 5 4 1 0  AZI 1 h ACE 2 h
63 1.25 2.30 148.7 -1.46 -0.19 18.0 80 14 4 11 8 10 1 0  AZI 1 h ACE 2 h
64 1.25 1.44 147.9 -1.98 -0.40 18.0 84 12 5 14 7 7 1 0  AZI 1 e ACE 2 e
65 1.31 1.78 147.9 -2.24 -0.44 22.1 85 14 6 11 5 5 2 0  AZI 1 e ACE 2 e
66 1.33 1.78 146.8 -2.34 -0.48 20.7 84 14 5 11 3 6 1 0  AZI 1 h ACE 2 h
67 1.23 2.32 149.0 -1.53 -0.25 17.7 83 12 6 14 7 9 0 0  AZI 1 h ACE 2 h
68 1.27 1.76 147.4 -2.16 -0.43 18.4 83 13 4 15 6 6 2 0  AZI 1 e ACE 2 e
69 1.29 1.78 149.5 -1.64 -0.25 17.7 78 12 4 11 8 7 3 0  AZI 1 e ACE 2 e
70 1.31 1.78 147.5 -2.13 -0.47 18.3 87 14 5 15 4 5 1 0  AZI 1 e ACE 2 e
71 1.33 1.78 147.1 -1.95 -0.36 18.7 85 15 3 15 7 5 1 0  AZI 1 h ACE 2 h
72 1.33 1.78 147.7 -2.03 -0.43 19.3 85 14 5 14 6 7 1 0  AZI 1 e ACE 2 e
73 1.23 2.16 151.4 -1.00 -0.14 14.5 80 12 2 13 10 11 1 0  AZI 1 h ACE 2 h
74 1.28 1.75 149.5 -2.07 -0.41 17.9 84 13 4 15 6 5 2 0  AZI 1 h ACE 2 h
75 1.33 1.78 148.5 -2.05 -0.34 18.7 84 15 2 15 7 6 1 0  AZI 1 e ACE 2 e
76 1.29 1.75 148.4 -2.08 -0.41 19.4 85 14 5 14 6 8 1 0  AZI 1 h ACE 2 h
77 1.23 2.18 149.6 -1.57 -0.21 17.8 79 11 4 13 7 13 1 0  AZI 1 h ACE 2 h
78 1.18 1.33 149.2 -1.25 -0.30 14.3 82 13 3 13 9 5 2 0  AZI 1 h ACE 2 h
79 1.20 2.13 149.7 -2.07 -0.44 17.9 85 12 5 15 6 7 1 0  AZI 1 e ACE 2 e
80 1.33 1.78 151.3 -1.68 -0.30 17.2 80 12 4 12 7 7 3 0  AZI 1 e ACE 2 e
81 1.23 2.17 152.3 -1.40 -0.23 16.2 81 14 4 14 7 11 0 1  AZI 1 h ACE 2 h
82 1.30 1.78 151.2 -1.71 -0.33 17.1 80 12 4 12 6 7 3 0  AZI 1 h ACE 2 h
83 1.23 2.18 152.9 -1.79 -0.26 21.1 80 16 5 12 6 10 0 0  AZI 1 h ACE 2 h
84 1.30 1.75 152.5 -1.56 -0.29 16.6 84 14 4 10 9 6 1 0  AZI 1 e ACE 2 e
85 1.34 1.77 151.1 -2.24 -0.46 21.0 86 14 6 13 4 5 1 0  AZI 1 h ACE 2 h
86 1.33 1.78 150.3 -2.15 -0.39 18.7 86 15 2 15 6 6 1 0  AZI 1 e ACE 2 e
87 1.24 2.33 152.0 -1.65 -0.26 20.8 82 17 5 12 8 10 1 0  AZI 1 h ACE 2 h
88 1.34 1.77 151.6 -2.14 -0.40 18.3 86 15 3 16 6 6 1 0  AZI 1 h ACE 2 h
89 1.27 1.78 152.9 -1.39 -0.30 14.5 83 13 1 13 8 6 2 0  AZI 1 e ACE 2 e
90 1.24 2.17 152.9 -1.72 -0.26 20.3 80 14 6 10 6 10 0 0  AZI 1 h ACE 2 h
91 1.29 2.29 155.6 -1.57 -0.23 17.9 80 13 5 14 9 9 1 0  AZI 1 h ACE 2 h
92 1.29 2.28 156.9 -1.40 -0.38 16.3 85 9 11 16 9 9 2 0  AZI 1 h ACE 2 h
93 1.21 2.23 154.5 -1.54 -0.24 18.9 82 14 6 13 9 11 0 0  AZI 1 h ACE 2 h
94 1.28 1.78 154.7 -1.52 -0.34 14.6 84 13 1 14 7 6 2 0  AZI 1 e ACE 2 e
95 1.26 2.33 157.3 -1.16 -0.13 16.8 77 12 5 11 10 11 2 0  AZI 1 h ACE 2 h
96 1.27 1.79 154.2 -1.65 -0.33 16.4 85 14 4 11 8 6 1 0  AZI 1 e ACE 2 e
97 1.24 2.20 157.2 -1.69 -0.26 20.8 82 14 7 12 7 9 0 0  AZI 1 h ACE 2 h
98 1.24 2.21 157.7 -1.57 -0.21 18.1 82 15 3 15 9 10 0 0  AZI 1 h ACE 2 h
99 1.24 2.21 158.8 -1.55 -0.25 17.0 82 11 3 14 7 11 0 0  AZI 1 h ACE 2 h
100 1.22 1.31 160.1 -1.06 -0.16 14.8 80 13 2 13 11 10 1 0  AZI 1 h ACE 2 h
101 1.26 2.20 164.4 -1.43 -0.21 16.8 81 15 4 12 8 10 1 0  AZI 1 h ACE 2 h
102 1.26 2.22 162.9 -1.67 -0.30 17.6 84 14 4 16 7 10 0 0  AZI 1 h ACE 2 h
103 1.26 2.22 167.8 -1.00 -0.15 13.9 81 13 2 14 10 11 1 0  AZI 1 h ACE 2 h
104 1.26 2.22 166.6 -1.71 -0.30 20.6 83 18 5 13 9 10 1 0  AZI 1 h ACE 2 h
105 1.28 2.20 169.3 -1.64 -0.31 17.6 84 15 6 15 7 9 0 0  AZI 1 h ACE 2 h
106 1.26 2.23 168.1 -1.77 -0.31 19.5 81 15 6 11 6 10 0 0  AZI 1 h ACE 2 h
107 1.29 2.34 169.1 -1.59 -0.26 17.0 80 14 5 15 9 10 1 0  AZI 1 h ACE 2 h
108 1.25 1.26 169.7 -1.67 -0.27 20.4 82 15 7 11 8 9 1 0  AZI 1 h ACE 2 h
109 1.25 2.26 169.5 -1.47 -0.25 18.0 83 15 6 14 9 11 0 0  AZI 1 h ACE 2 h
110 1.21 2.16 171.4 -1.60 -0.29 17.3 82 13 6 15 9 11 0 0  AZI 1 h ACE 2 h
111 1.27 2.25 173.0 -1.28 -0.16 16.9 78 13 5 12 10 11 2 0  AZI 1 h ACE 2 h
112 1.28 2.24 176.4 -1.11 -0.20 14.4 81 14 2 14 10 10 1 0  AZI 1 h ACE 2 h
113 1.19 1.32 24.5 -0.30 -0.08 2.3 73 0 0 2 1 2 2 0  
114 1.19 1.31 24.7 -0.36 -0.02 2.2 78 0 0 3 1 2 2 0  
115 1.36 1.45 15.6 -0.10 0.04 15.6 85 1 2 1 3 1 0 0  

Residue-type_colouring
Positive Negative Neutral Aliphatic Aromatic Pro & Gly Cysteine
H,K,R D,E S,T,N,Q A,V,L,I,M F,Y,W P,G C

Acknowledgement
Tunnels were calculated by MOLE 2.0 program version 2.5.13.11.08 and visualized using Pymol 0.97rc.
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