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PDBsum entry 4xqo
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Viral protein
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PDB id
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4xqo
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References listed in PDB file
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Key reference
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Title
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A human-Infecting h10n8 influenza virus retains a strong preference for avian-Type receptors.
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Authors
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H.Zhang,
R.P.De vries,
N.Tzarum,
X.Zhu,
W.Yu,
R.Mcbride,
J.C.Paulson,
I.A.Wilson.
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Ref.
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Cell Host Microbe, 2015,
17,
377-384.
[DOI no: ]
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PubMed id
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Abstract
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Recent avian-origin H10N8 influenza A viruses that have infected humans pose a
potential pandemic threat. Alterations in the viral surface glycoprotein,
hemagglutinin (HA), typically are required for influenza A viruses to cross the
species barrier for adaptation to a new host, but whether H10N8 contains
adaptations supporting human infection remains incompletely understood. We
investigated whether H10N8 HA can bind human receptors. Sialoside glycan
microarray analysis showed that the H10 HA retains a strong preference for avian
receptor analogs and negligible binding to human receptor analogs. Crystal
structures of H10 HA with avian and human receptor analogs revealed the basis
for preferential recognition of avian-like receptors. Furthermore, introduction
of mutations into the H10 receptor-binding site (RBS) known to convert other HA
subtypes from avian to human receptor specificity failed to switch preference to
human receptors. Collectively, these findings suggest that the current H10N8
human isolates are poorly adapted for efficient human-to-human transmission.
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