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PDBsum entry 4l4v
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Membrane protein/immune system
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PDB id
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4l4v
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Contents |
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262 a.a.
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99 a.a.
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200 a.a.
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243 a.a.
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188 a.a.
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References listed in PDB file
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Key reference
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Title
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Recognition of vitamin b metabolites by mucosal-Associated invariant t cells.
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Authors
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O.Patel,
L.Kjer-Nielsen,
J.Le nours,
S.B.Eckle,
R.Birkinshaw,
T.Beddoe,
A.J.Corbett,
L.Liu,
J.J.Miles,
B.Meehan,
R.Reantragoon,
M.L.Sandoval-Romero,
L.C.Sullivan,
A.G.Brooks,
Z.Chen,
D.P.Fairlie,
J.Mccluskey,
J.Rossjohn.
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Ref.
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Nat Commun, 2013,
4,
2142.
[DOI no: ]
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PubMed id
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Abstract
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The mucosal-associated invariant T-cell antigen receptor (MAIT TCR) recognizes
MR1 presenting vitamin B metabolites. Here we describe the structures of a human
MAIT TCR in complex with human MR1 presenting a non-stimulatory ligand derived
from folic acid and an agonist ligand derived from a riboflavin metabolite. For
both vitamin B antigens, the MAIT TCR docks in a conserved manner above MR1,
thus acting as an innate-like pattern recognition receptor. The invariant MAIT
TCR α-chain usage is attributable to MR1-mediated interactions that prise open
the MR1 cleft to allow contact with the vitamin B metabolite. Although the
non-stimulatory antigen does not contact the MAIT TCR, the stimulatory antigen
does. This results in a higher affinity of the MAIT TCR for a stimulatory
antigen in comparison with a non-stimulatory antigen. We formally demonstrate a
structural basis for MAIT TCR recognition of vitamin B metabolites, while
illuminating how TCRs recognize microbial metabolic signatures.
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