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PDBsum entry 4l3v
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PDB id:
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Lyase
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Title:
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Crystal structure of delta516-525 human cystathionine beta-synthase
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Structure:
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Cystathionine beta-synthase. Chain: b, a, c. Synonym: beta-thionase, serine sulfhydrase. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: cbs. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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3.63Å
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R-factor:
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0.217
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R-free:
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0.232
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Authors:
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J.Ereno,T.Majtan,I.Oyenarte,J.P.Kraus,L.A.Martinez
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Key ref:
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J.Ereño-Orbea
et al.
(2013).
Structural basis of regulation and oligomerization of human cystathionine β-synthase, the central enzyme of transsulfuration.
Proc Natl Acad Sci U S A,
110,
E3790.
PubMed id:
DOI:
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Date:
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07-Jun-13
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Release date:
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18-Sep-13
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PROCHECK
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Headers
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References
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P35520
(CBS_HUMAN) -
Cystathionine beta-synthase from Homo sapiens
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Seq:
Struc:
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551 a.a.
498 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.4.2.1.22
- cystathionine beta-synthase.
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Reaction:
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L-homocysteine + L-serine = L,L-cystathionine + H2O
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L-homocysteine
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+
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L-serine
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=
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L,L-cystathionine
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+
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H2O
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Cofactor:
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Pyridoxal 5'-phosphate
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Pyridoxal 5'-phosphate
Bound ligand (Het Group name =
PLP)
matches with 93.75% similarity
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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DOI no:
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Proc Natl Acad Sci U S A
110:E3790
(2013)
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PubMed id:
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Structural basis of regulation and oligomerization of human cystathionine β-synthase, the central enzyme of transsulfuration.
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J.Ereño-Orbea,
T.Majtan,
I.Oyenarte,
J.P.Kraus,
L.A.Martínez-Cruz.
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ABSTRACT
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Links
