PDBsum entry 3wik

Transferase

PDB id: 3wik

Contents

Protein chain

334 a.a.

Ligands

LCT

Waters ×163

PDB id:

3wik

Name:

Transferase

Title:

Crystal structure of the ck2alpha/compound10 complex

Structure:

Casein kinase ii subunit alpha. Chain: a. Fragment: unp residues 1-335. Synonym: ck ii alpha. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: csnk2a1, ck2a1. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.00Å R-factor: 0.166 R-free: 0.211

Authors:

T.Kinoshita,T.Nakaniwa,Y.Sekiguchi,I.Nakanishi

Key ref:

I.Nakanishi et al. Identification of protein kinase ck2 inhibitors using solvent dipole ordering virtual screening. To be published, . PubMed id: 25912672

Date:

18-Sep-13 Release date: 05-Nov-14

Protein chain

P68400  (CSK21_HUMAN) -  Casein kinase II subunit alpha from Homo sapiens

Seq: 391 a.a.

Struc: 334 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site