PDBsum entry 3v5k

Immune system

PDB id: 3v5k

Contents

Protein chains

275 a.a.

100 a.a.

Ligands

LYS-VAL-ALA-GLU-LEU-VAL-TRP-PHE-LEU ×2

GOL

Waters ×289

PDB id:

3v5k

Name:

Immune system

Title:

Hla2.1 kvaelvwfl

Structure:

Hla class i histocompatibility antigen, a-2 alpha chain. Chain: a, d. Synonym: mhc class i antigen a 2. Engineered: yes. Beta-2-microglobulin. Chain: b, e. Synonym: beta-2-microglobulin form pi 5.3. Engineered: yes. HIV-based altered-peptide ligand kvaelvwfl.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hla 0201, Hla-a, hlaa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: b2m, beta-2-microglobulin, cdabp0092, hdcma22p. Synthetic: yes. Other_details: chemically synthesized peptide based on sequence from

Resolution:

2.31Å R-factor: 0.188 R-free: 0.228

Authors:

E.J.Collins,H.Y.Lee

Key ref:

E.J.Collins and h.y.lee Prediction of immunogenicity of altered-Peptide ligan HIV bound to mhc. To be published, .

Date:

16-Dec-11 Release date: 19-Dec-12

Protein chains

P04439  (1A03_HUMAN) -  HLA class I histocompatibility antigen, A alpha chain from Homo sapiens

Seq: 365 a.a.

Struc: 275 a.a.*

Protein chains

P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens

Seq: 119 a.a.

Struc: 100 a.a.*

* PDB and UniProt seqs differ at 20 residue positions (black crosses)