PDBsum entry 3ryb

Peptide binding protein

PDB id: 3ryb

Contents

Protein chain

563 a.a.

Ligands

SER-LEU-SER-GLN-SER-LEU-SER-GLN-SER

Waters ×859

References listed in PDB file

Key reference

• Title: Importance of a hydrophobic pocket for peptide binding in lactococcal oppa.
• Authors: R.P.Berntsson, A.M.Thunnissen, B.Poolman, D.J.Slotboom.
• Ref.: J Bacteriol, 2011, 193, 4254-4256.
• PubMed id: 21665971

Abstract

Lactococcal oligopeptide-binding protein A (OppA) binds peptides with widely varied lengths and sequences. We previously hypothesized that a hydrophobic pocket in OppA preferentially binds a hydrophobic peptide side chain and thus determines its binding register. Two crystal structures of OppA with different nonapeptides now indeed show binding in different registers.